Radiation-induced genomic instability: manifestations and mechanisms

作者: E.G. Wright

DOI: 10.1504/IJLR.2004.003875

关键词: Cell typeCell biologyGenetic predispositionGeneticsMutationBiologyGene mutationGenome instabilityMechanism (biology)Bystander effectEpigenetics

摘要: There is considerable evidence that delayed death, gene mutations and a variety of chromosomal abnormalities can be demonstrated in cells are not themselves irradiated but the progeny exposed to ionising radiation many cell divisions previously. These effects collectively referred as radiation-induced genomic instability. At present, we have limited understanding underlying mechanism(s) there differences expression instability between different types strong dependence on genetic factors ("genetic predisposition"). In all studies where been they reproducibly at frequencies considerably greater than conventional mutation arguing against being due "conventional" mutational mechanisms Current favours epigenetic free radical-mediated processes suggested. Such could explain data demonstrating develop by an indirect inter-cellular ("bystander") mechanism. Radiation-induced bystander result unirradiated exhibiting responses typically associated with exposure consequence contact or receiving soluble signals from cells. Bystander instabilities may reflect inter-related aspects non-targeted non-specific inflammatory-type stress injury.

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