The onset and extent of genomic instability in sporadic colorectal tumor progression

摘要: Cancer cell genomes contain alterations beyond known etiologic events, but their total number has been unknown at even the order of magnitude level. By sampling colorectal premalignant polyp and carcinoma through use technique inter-(simple sequence repeat) PCR, we have found genomic to be considerably more abundant than expected, with mean events per totaling approximately 11,000. Colonic polyps early in tumor progression pathway showed similar numbers events. These results indicate that, as certain hereditary cancer syndromes, destabilization is an step sporadic development. Together these support model instability being a cause rather effect malignancy, facilitating vastly accelerated somatic evolution, observed orderly steps colon reflecting consequences natural selection.