The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

作者: Richard Fishel , Mary Kay Lescoe , M.R.S. Rao , Neal G. Copeland , Nancy A. Jenkins

DOI: 10.1016/0092-8674(93)90546-3

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摘要: We have identified a human homolog of the bacterial MutS and S. cerevisiae MSH proteins, called hMSH2. Expression of hMSH2 in E. coli causes a dominant mutator phenotype, …

参考文章(67)
Liguo New, Kang Liu, Gray F. Crouse, The yeast gene MSH3 defines a new class of eukaryotic MutS homologues Molecular Genetics and Genomics. ,vol. 239, pp. 97- 108 ,(1993) , 10.1007/BF00281607
P Modrich, Methyl-directed DNA mismatch correction. Journal of Biological Chemistry. ,vol. 264, pp. 6597- 6600 ,(1989) , 10.1016/S0021-9258(18)83467-6
R.F. Roscigno, M. Weiner, M.A. Garcia-Blanco, A mutational analysis of the polypyrimidine tract of introns: Effects of sequence differences in pyrimidine tracts on splicing Journal of Biological Chemistry. ,vol. 268, pp. 11222- 11229 ,(1993) , 10.1016/S0021-9258(18)82114-7
S P Moore, R Fishel, Purification and characterization of a protein from human cells which promotes homologous pairing of DNA. Journal of Biological Chemistry. ,vol. 265, pp. 11108- 11117 ,(1990) , 10.1016/S0021-9258(19)38564-3
P.L. Icely, P. Gros, J.J. Bergeron, A. Devault, D.E. Afar, J.C. Bell, TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. Journal of Biological Chemistry. ,vol. 266, pp. 16073- 16077 ,(1991) , 10.1016/S0021-9258(18)98517-0
D C Thomas, J D Roberts, T A Kunkel, Heteroduplex repair in extracts of human HeLa cells Journal of Biological Chemistry. ,vol. 266, pp. 3744- 3751 ,(1991) , 10.1016/S0021-9258(19)67858-0
M Grilley, K M Welsh, S S Su, P Modrich, Isolation and characterization of the Escherichia coli mutL gene product. Journal of Biological Chemistry. ,vol. 264, pp. 1000- 1004 ,(1989) , 10.1016/S0021-9258(19)85043-3
D.L. Cooper, R.S. Lahue, P. Modrich, Methyl-directed mismatch repair is bidirectional. Journal of Biological Chemistry. ,vol. 268, pp. 11823- 11829 ,(1993) , 10.1016/S0021-9258(19)50274-5
Andrew Berchuck, John I. Risinger, Patrice Watson, Henry T. Lynch, Jeff Boyd, Matthew F. Kohler, Genetic instability of microsatellites in endometrial carcinoma. Cancer Research. ,vol. 53, pp. 5100- 5103 ,(1993)