Preclinical evaluation of a Raman spectroscopic probe for endoscopic classification of oesophageal pathologies

摘要: Raman spectroscopy is an inelastic scattering technique capable of probing the biochemical changes associated with neoplastic progression in oesophageal tissue. Custom-built fibre-optic probes could potentially provide opportunities for vivo endoscopic diagnosis pre-cancerous lesions and targeted early therapy. However, prior to commencing a clinical trial convincing ex work must demonstrate multi-operator, multi-centre and multi-system reliability. We report spectral consistency between two operators who independently evaluated two optically identical vivo. In addition, we compatibility with high-definition white light endoscopes and narrow band imaging systems highlighting potential future multi-modality the oesophagus.