Beyond the Flavour: The Potential Druggability of Chemosensory G Protein-Coupled Receptors
作者： Antonella Di Pizio , Maik Behrens , Dietmar Krautwurst
DOI: 10.3390/IJMS20061402
关键词: G protein-coupled receptor 、 Receptor 、 Taste 、 Druggability 、 Biology 、 Cell biology 、 Umami 、 Chemical space 、 Taste receptor 、 Flavour
摘要: … /TAS1R3 combination recognizes natural and artificial … against TAS2Rs is not enough for their repurposing to TAS2R… [165], is the most potent known TAS2R agonist but its activity …
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sci-hub.se 参考文章(196)
B. Suess, D. Festring, T. Hofmann, Umami compounds and taste enhancers Flavour Development, Analysis and Perception in Food and Beverages. pp. 331- 351 ,(2015) , 10.1016/B978-1-78242-103-0.00015-1
Joshua N. Fletcher, Li Pan, A. Douglas Kinghorn, Medicinal Chemistry of Plant Naturals as Agonists/Antagonists for Taste Receptors Springer, Cham. pp. 35- 71 ,(2014) , 10.1007/7355_2014_81
Dietmar Krautwurst, Matthias Kotthoff, A hit map-based statistical method to predict best ligands for orphan olfactory receptors: natural key odorants versus "lock picks". Methods of Molecular Biology. ,vol. 1003, pp. 85- 97 ,(2013) , 10.1007/978-1-62703-377-0_6
Kenneth A. Jacobson, New paradigms in GPCR drug discovery Biochemical Pharmacology. ,vol. 98, pp. 541- 555 ,(2015) , 10.1016/J.BCP.2015.08.085
Maik Behrens, Wolfgang Meyerhof, Oral and Extraoral Bitter Taste Receptors Results and problems in cell differentiation. ,vol. 52, pp. 87- 99 ,(2011) , 10.1007/978-3-642-14426-4_8
Hiroaki Matsunami, Jean-Pierre Montmayeur, Linda B. Buck, A family of candidate taste receptors in human and mouse Nature. ,vol. 404, pp. 601- 604 ,(2000) , 10.1038/35007072
Tudor I. Oprea, Property distribution of drug-related chemical databases Journal of Computer-aided Molecular Design. ,vol. 14, pp. 251- 264 ,(2000) , 10.1023/A:1008130001697
Ester Feldmesser, Tsviya Olender, Miriam Khen, Itai Yanai, Ron Ophir, Doron Lancet, Widespread ectopic expression of olfactory receptor genes BMC Genomics. ,vol. 7, pp. 121- 121 ,(2006) , 10.1186/1471-2164-7-121
Bryan L. Roth, Wesley K. Kroeze, Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily Journal of Biological Chemistry. ,vol. 290, pp. 19471- 19477 ,(2015) , 10.1074/JBC.R115.654764
Ole G. Mouritsen, Himanshu Khandelia, Molecular mechanism of the allosteric enhancement of the umami taste sensation FEBS Journal. ,vol. 279, pp. 3112- 3120 ,(2012) , 10.1111/J.1742-4658.2012.08690.X