Heteroaromatic N-Oxides in Asymmetric Catalysis: A Review.

摘要: An increasing interest in the synthesis and use of optically active pyridine N-oxides as chiral controllers for asymmetric reactions has been observed last few years. Chiral heteroaromatic can work powerful electron-pair donors, providing suitable electronic environments transition state formed within reaction. The nucleophilicity oxygen atom N-oxides, coupled with a high affinity silicon to oxygen, represent ideal properties development synthetic methodology based on nucleophilic activation organosilicon reagents. application efficient organocatalysts allylation, propargylation, allenylation, ring-opening meso-epoxides, well ligands metal complexes catalyzing Michael addition or nitroaldol reaction, also be found literature. This review deals stereoselective applications how differentiating are correlated their structure. It contains more recent results, covering approximately ten All reported examples have divided into five classes, according chirality elements present basic molecular frameworks.