Efficacy and safety of enoxaparin versus unfractionated heparin for prevention of deep venous thrombosis after elective knee arthroplasty. Enoxaparin Clinical Trial Group.

摘要: This study was a randomized, parallel-group, open-label clinical trial comparing the efficacy and safety of Enoxaparin, low-molecular-weight heparin, unfractionated heparin to prevent deep venous thrombosis after elective total knee arthroplasty. Four hundred fifty-three patients were randomized received medications. The primary evaluation unilateral contrast venography done at end or earlier if clinically indicated. outcome incidence bleeding episodes. Patients assigned 1 2 postoperative treatment groups: Enoxaparin 30 mg subcutaneous every 12 hours (228 patients), 5000 units 8 (225 patients). proximal distal in group 24.6% (56/228), 34.2% (77/225). Three major hemorrhagic episodes observed each group. Two cases pulmonary embolism occurred receiving (1 fatal); no Enoxaparin. showed that administered postoperatively is more effective as safe prophylaxis having