Effects of Delayed Intraischemic and Postischemic Hypothermia on a Focal Model of Transient Cerebral Ischemia in Rats
作者： Nobuyuki Kawai , Masanobu Okauchi , Kuniaki Morisaki , Seigo Nagao
关键词: Vascular disease 、 Infarction 、 Central nervous system disease 、 Neuroprotection 、 Medicine 、 Infarct volume 、 Cerebral infarction 、 Anesthesia 、 Hypothermia 、 Ischemia
摘要: Background and Purpose—Intraischemic mild hypothermia has been shown to be neuroprotective in reducing cerebral infarction transient focal ischemia. As a more clinical relevant issue, we investigated the effect of delayed intraischemic postischemic on rat model reversible We also examined inflammatory response after ischemia-reperfusion assess mechanism brain hypothermia. Methods—Rats were subjected 2 hours middle artery occlusion followed by 22 reperfusion under following protocols: (1) rats treated with normothermia (37.0°C, 4 hours) then housed room temperature (25°C, 18 (2) (33.0°C, hours, modulation was started 30 minutes before reperfusion) cold (5°C, hours). Animals killed 24 onset The infarct volume was...
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