Phosphoinositide regulation of TRPV1 revisited

摘要: The heat- and capsaicin-sensitive transient receptor potential vanilloid 1 ion channel (TRPV1) is regulated by plasma membrane phosphoinositides. effects of these lipids on this have been controversial. Recent articles re-ignited the debate also offered resolution to place some data in a coherent picture. This review summarizes literature topic provides detailed critical discussion experimental evidence for various phosphatidylinositol 4,5-bisphosphayte [PI(4,5)P2 or PIP2] TRPV1. We conclude that PI(4,5)P2 potentially its precursor PI(4)P are positive cofactors TRPV1, acting via direct interaction with channel, their depletion Ca(2+)-induced activation phospholipase Cδ isoforms (PLCδ) limits activity during capsaicin-induced desensitization. Other negatively charged at higher concentrations can support activity, which may explain controversies literature. partially inhibits settings, relief from inhibition upon PLCβ contribute sensitization. negative effect more controversial mechanism less well understood. TRP channels TRPV TRPC families undergo similar dual regulation phosphoinositides, thus complexity TRPV1 not unique channel.