TRPV1: A Target for Rational Drug Design
作者： Vincenzo Carnevale , Tibor Rohacs
DOI: 10.3390/PH9030052
关键词:
摘要: Transient Receptor Potential Vanilloid 1 (TRPV1) is a non-selective, Ca2+ permeable cation channel activated by noxious heat, and chemical ligands, such as capsaicin resiniferatoxin (RTX). Many compounds have been developed that either activate or inhibit TRPV1, but none of them are in routine clinical practice. This review will discuss the rationale for antagonists agonists TRPV1 pain relief other conditions, strategies to develop new, better drugs target this ion channel, using newly available high-resolution structures.
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