Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists.
作者： Mojgan Aghazadeh Tabrizi , Pier Giovanni Baraldi , Stefania Baraldi , Stefania Gessi , Stefania Merighi
DOI: 10.1002/MED.21427
关键词:
摘要: Transient receptor potential vanilloid 1 (TRPV1) is an ion channel expressed on sensory neurons triggering an influx of cations. TRPV1 receptors function as homotetramers …
sci-hub.se 参考文章(289)
A. Miranda, E. Nordstrom, A. Mannem, C. Smith, B. Banerjee, J.N. Sengupta, The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis Neuroscience. ,vol. 148, pp. 1021- 1032 ,(2007) , 10.1016/J.NEUROSCIENCE.2007.05.034
Megumi Kikuchi, Hideaki Shirasaki, Nobuhiko Seki, Tetsuo Himi, Naoto Watanabe, Tatsuo Sakamoto, Expression and localization of TRPV1 in human nasal mucosa Rhinology. ,vol. 44, pp. 128- 134 ,(2006)
Francesca Fruttarolo, Marcello Trevisani, Pierangelo Geppetti, Maria Giovanna Pavani, Pier Giovanni Baraldi, Pier Andrea Borea, VR1 vanilloid receptor antagonists with a iononic substructure ,(2007)
M S Grace, M Baxter, E Dubuis, M A Birrell, M G Belvisi, Transient receptor potential (TRP) channels in the airway: role in airway disease. British Journal of Pharmacology. ,vol. 171, pp. 2593- 2607 ,(2014) , 10.1111/BPH.12538
Peter M. Zygmunt, Jesper Petersson, David A. Andersson, Huai-hu Chuang, Morten Sørgård, Vincenzo Di Marzo, David Julius, Edward D. Högestätt, Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide Nature. ,vol. 400, pp. 452- 457 ,(1999) , 10.1038/22761
Louis S. Premkumar, Gerard P. Ahern, Induction of vanilloid receptor channel activity by protein kinase C Nature. ,vol. 408, pp. 985- 990 ,(2000) , 10.1038/35050121
Fabiana N Dornelles, Edinéia L Andrade, Maria M Campos, João B Calixto, Role of CXCR2 and TRPV1 in functional, inflammatory and behavioural changes in the rat model of cyclophosphamide-induced haemorrhagic cystitis. British Journal of Pharmacology. ,vol. 171, pp. 452- 467 ,(2014) , 10.1111/BPH.12467
Michael J. Caterina, Mark A. Schumacher, Makoto Tominaga, Tobias A. Rosen, Jon D. Levine, David Julius, The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature. ,vol. 389, pp. 816- 824 ,(1997) , 10.1038/39807
Ahmed A. Othman, Wolfram Nothaft, Walid M. Awni, Sandeep Dutta, Effects of the TRPV1 antagonist ABT-102 on body temperature in healthy volunteers: pharmacokinetic/ pharmacodynamic analysis of three phase 1 trials. British Journal of Clinical Pharmacology. ,vol. 75, pp. 1029- 1040 ,(2013) , 10.1111/J.1365-2125.2012.04405.X
Thomas Christoph, Bernhard Lesch, Robert Frank, Jeewoo Lee, Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands ,(2011)