The REACH concept and its impact on toxicological sciences.

摘要: Currently, comprehensive toxicological data are available only for a small percentage of the 30,000 substances produced in volumes 1-100 tons per year EU. Substances with inadequate safety sets may pose risk to employees, consumers and environment. To improve this unsatisfactory situation European Commission put forward draft concept that will probably become law 2006. The acronym is REACH standing Registration, Evaluation Authorization Chemicals. aim systematically evaluate approximately chemical produced, used or imported quantities year. From practical point view testing requirements these chemicals one most important parts proposal. latter progressively increase volume substances, including, e.g. acute, subchronic chronic toxicity tests. Without doubt provide an contribution health protection workers consumers. But perhaps even more importantly, offers opportunity optimize innovate strategies chemicals. Such novel techniques particular RNA expression profiling, proteome analysis metabonomics describe alterations gene protein expressions patterns metabolite concentrations response toxic stimuli. Promising have been published indicating might identify hepato- nephrotoxic compounds carcinogens differentiating between genotoxic non-genotoxic substances. However, so far relatively number selected typical well known mechanisms has tested. Therefore, promising innovative should be optimized validated by investigating series other but also untypical In further step supplementary research program launched including (e.g. genomics, proteomics, metabonomics) alternative methods vitro QSAR), concentrating on same tested conventional animal studies mandatory part REACH. present review we summarize key features REACH, discuss possibilities development improved integrated testing.