Molecular basis of gastric carcinogenesis
作者： G. Nardone
DOI: 10.1046/J.1365-2036.17.S2.10.X
关键词: Genetics 、 Cancer 、 Cell 、 Helicobacter pylori 、 Gene 、 Environmental Risk Factor 、 Biology 、 Phenotype 、 Transformation (genetics) 、 Microsatellite Mutator Phenotype
摘要: Gastric cancer is constituted by two histomorphological entities 'intestinal' and 'diffuse', however lesions with similar morphologies may differ in biological aggressiveness response to therapy. Two distinct molecular pathways have been identified gastric carcinogenesis: the microsatellite mutator phenotype a associated chromosomal intrachromosomal instability. Mounting evidence suggests that alterations expression of products cancer-related genes are early markers cell transformation, serve identify carcinoma histotypes. The lack clear genetic basis, lends weight notion not monomorphic entity but be affected environmental factors. Helicobacter pylori most important risk factor sporadic cancer. Exposure epithelial cells bacterium results generation reactive oxygen species inducible nitric oxide synthase turn cause leading subset subjects. Thus, considered result an interplay between host profile toxic agents. new technologies analysis will help establish individual's developing lead novel therapeutic strategies.
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