Phenotypic and Genotypic Events in Gastric Carcinogenesis

摘要: Two main histological variants of gastric carcinoma have been identified: intestinal and diffuse types. The former is preceded by a sequential chain events characterized as chronic gastritis, atrophy, metaplasia, dysplasia, intramucosal carcinoma, invasive neoplasia. second type (diffuse) lacks well-recognized precursor changes. Genotypic in the precancerous process are described, but clear model their sequence relevance lacking. Cadherins may play role determining which develops. Translocated promoter region-MET rearrangements identified since early stages process. p53 alterations reported beginning with dysplasia stage utilizing immunohistochemical techniques. Single-strand conformation polymorphism sequencing analysis show stages, especially G:C to A:T transitions.