Prognostic significance of molecular biological and immunohistological parameters in gastrointestinal carcinomas.

作者: J. Rüschoff , T. Bocker , P. Vogel , J. Schlegel

DOI: 10.1007/978-3-642-80035-1_6

关键词:

摘要: Histological type, malignancy grade, and tumor stage are among the most important parameters predicting outcome in cancer patients Making use of immunocytochemistry as well polymerase chain reaction-based techniques demonstration micrometastatic spread, for example, into bone marrow, lymph nodes, peritoneal cavity, is a new staging parameter prognostic significance. In contrast, value different proliferation markers such Ki67 (Mib 1), PCNA, AgNOR has not yet been unequivocally established.

参考文章(66)
Peter Beighton, Greta Beighton, de la Chapelle, A. The Person Behind the Syndrome. pp. 209- 209 ,(1997) , 10.1007/978-1-4471-0925-9_118
H.-D. Flad, G. Key, M. Duchrow, J. Gerdes, M. H. G. Becker, B. Baron, C. Schlüter, New Ki-67-equivalent murine monoclonal antibodies (MIB 1-3) generated against bacterially expressed parts of the Ki-67 cDNA containing three 62 base pair repetitive elements encoding for the Ki-67 epitope. Laboratory Investigation. ,vol. 68, pp. 629- 636 ,(1993)
R. Parwaresch, H. H. Wacker, H. Kreipe, M. Hauberg, K. Haas, M. Tiemann, H. J. Heidebrecht, Determination of the growth fraction in non-Hodgkin's lymphomas by monoclonal antibody Ki-S5 directed against a formalin-resistant epitope of the Ki-67 antigen. American Journal of Pathology. ,vol. 142, pp. 1689- 1694 ,(1993)
D. P. Hollywood, N. R. Lemoine, Growth Factors, Oncogenes and Tumour Suppressor Genes Assessment of Cell Proliferation in Clinical Practice. pp. 27- 43 ,(1992) , 10.1007/978-4-431-68287-5_2
J. Rüschoff, K. Plate, A. Bittinger, C. Thomas, Nucleolar organizer regions (NORs). Basic concepts and practical application in tumor pathology. Pathology Research and Practice. ,vol. 185, pp. 878- 885 ,(1989) , 10.1016/S0344-0338(89)80290-0
Babette Simon, Rolf Weinel, Martin Höhne, Jutta Watz, Jörg Schmidt, Günther Körtner, Rudolf Arnold, Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma Gastroenterology. ,vol. 106, pp. 1645- 1651 ,(1994) , 10.1016/0016-5085(94)90422-7
Graham Dm, Appelman Hd, Crohn's-like lymphoid reaction and colorectal carcinoma: a potential histologic prognosticator. Modern Pathology. ,vol. 3, pp. 332- 335 ,(1990)
Kanematsu T, Shiku H, Motojima K, Tsunoda T, Nagata Y, Urano T, Mutations in the Kirsten-ras oncogene are common but lack correlation with prognosis and tumor stage in human pancreatic carcinoma. The American Journal of Gastroenterology. ,vol. 86, pp. 1784- 1788 ,(1991)
D. B. Gough, P. Dervan, W. P. Joyce, M. Fynes, J. M. Fitzpatrick, K. T. Moran, T. F. Gorey, The prognostic value of nucleolar organiser regions in colorectal cancer: a 5-year follow-up study. Annals of The Royal College of Surgeons of England. ,vol. 74, pp. 172- ,(1992)