Application of Theranostics to Measure and Treat Cell Heterogeneity in Cancer

摘要: Individualized therapy is a noble anticipation in oncology. It would permit not only to adapt treatment an individual’s physiology and characteristics, but also pinpoint therapeutic features for each neoplasia. The high degree of cell heterogeneity cancer, with mixtures cells different origins populations that evolve toward multiple genomic epigenomic profiles, makes the precise targeting abnormal priority. phenotypic nature cancer largely determined by changes gene transcription requiring identification increasing number intracellular even intranuclear markers. Such requirement brings new challenges state-of-the-art technology focusing on single-cell analysis begs development nanotools can provide multiplex approach necessary target locations reach, detect, appropriately treat subgroups cells. In this chapter we introduce reader discuss how emerging knowledge has shed light difficulties encountered management neoplasias over past few decades. Our illustrates nanotheranostics might help effectively address issue halt progression, overcome resistance treatment, possibly decrease risks among individuals.