Microenvironment-Cell Nucleus Relationship in the Context of Oxidative Stress.

摘要: The microenvironment is a source of reactive oxygen species (ROS) that influence cell phenotype and tissue homeostasis. impact ROS on redox pathways as well directly epigenetic mechanisms the DNA illustrate communication with nucleus. Changes in gene transcription related to conditions also content structure extracellular matrix. However, importance microenvironmental for normal progression through life disease development still needs be thoroughly understood. We how different concentration levels trigger various intracellular linked nuclear functions determine processes necessary differentiation stem cells. abnormal predominance leads oxidative stress emphasized light its aging diseases aging. These phenomena are discussed context possible contribution via direct diffusion into cells responsible organ function, but an stromal triggers modifications influences mechanotransduction. Finally, we argue organs-on-a-chip controlled can help grasp whether production readily cause or consequence certain disorders, better understand induce switch phenotype.