Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death
作者： Luxi Sun , Rong Tan , Jianquan Xu , Justin LaFace , Ying Gao
DOI: 10.1093/NAR/GKV598
关键词: Telomere-binding protein 、 Cell biology 、 Telomeric Repeat Binding Protein 1 、 Cell aging 、 Heterochromatin 、 DNA repair 、 DNA damage 、 Biology 、 Senescence 、 Telomere 、 Molecular biology
摘要: Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telomere. Both oxidative stress and telomere shortening/dysfunction cause …
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