Molecular mechanisms of carcinogenesis in gastric cancer.
作者： Heinz Höfler , Karl-Friedrich Becker
DOI: 10.1007/978-3-642-59349-9_5
关键词:
摘要: The catalog of gene alterations in human cancer grows rapidly. Gastric is no exception and displays changes multiple oncogenes, suppressor genes, DNA repair genes. Clinically relevant molecules whose expression or structure altered include the plasminogen activator (uPA) its inhibitor PAI-1 (plasminogen type 1), cell-cycle regulator cyclin E, epidermal growth factor (EGF), apoptosis bcl-2, cell adhesion molecule E-cadherin, multifunctional protein beta-catenin. In addition, genetic instability commonly seen. Gene amplification overexpression receptors c-erbB2 K-sam may be prognostic factors for intestinal-type diffuse-type gastric cancer, respectively. clinical implications some recent findings diagnosis therapy are discussed.
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