Association between EGF +61A/G polymorphism and gastric cancer in Caucasians

摘要: AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght analyses were used genotype EGF +61 in 207 patients with lesions (162 adenocarcinomas, 45 atrophy or intestinal metaplasia) 984 controls. All subjects Caucasian. RESULTS: Genotype distribution was 23.5% for GG 76.5% GA/AA control group, 18.4% 68.6% entire group 17.9% 82.1% adenocarcinoma. No statistically significant associations found variants risk developing cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P 0.116]. However, stratification of individuals by gender revealed that males carrying A alleles (EGF AA) had an increased as compared homozygous (OR 1.55, CI: 1.05-2.28, 0.021). CONCLUSION: In summary, we who carriers cancer. This result may be explained suggestion women secrete less acid than men.