Lipid peroxidation as one mode of action in ochratoxin A toxicity in rats and chicks

摘要: The objective of this study was to determine whether lipid peroxidation is one mode action in ochratoxin A (OA) toxicity vivo. Lipid monitored by analyzing malondialdehyde (MDA) different tissues HPLC. refinement on the MDA assay carried out, which showed importance addition an iron catalyst for decomposition hydroperoxides yield a maximum amount from given sample. rat experiment designed 2 × 2 factorial arrangement using 4 × 6 animals. four diets were fed 21 d and contained either 1% corn oil 9% tallow (Diets I III) or 10% II IV); groups III IV, 5 mg OA added per kilogram diet. For chick 4 × 8 Leghorn cockerels received 14 d with no sunflower III), whereas IV supplemented 2.5% oil. In 2.5 mg both experiments ...