IN-VITRO CYTOTOXICITY IN OVARIAN-CANCER OF LOW-DOSE CONTINUOUS EXPOSURE TO MICROTUBULE INHIBITORS (PACLITAXEL TAXOTERE) COMBINED WITH CISPLATIN

摘要: We present our data on the cytotoxicity of microtubule inhibitors (paclitaxel and taxotere) their mode action against cisplatin-sensitive or -resistant ovarian cancer cell lines in vitro. To try to establish an optimal administration schedule clinical use, alone sequential combination with cisplatin was investigated. With microtubules alone, a marked dose- schedule-dependent growth inhibition demonstrated lower concentrations only schedule-dependency higher concentrations. The taxotere approximately 0.8- 132-fold that paclitaxel. No cross resistance observed. In relation between assay AUC (area under concentration curve) inhibition, increasing by dose escalation seemed not be advantageous. cisplatin, treatment over 48 h followed most effective cisplatin-resistant line.