Additive and supra-additive cytotoxicity of cisplatin-taxane combinations in ovarian carcinoma cell lines
作者： P Engblom , V Rantanen , J Kulmala , H Helenius , S Grènman
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摘要: The purpose of this study was to compare the growth-inhibitory effect cisplatin–paclitaxel with that obtained a cisplatin–docetaxel combination and assess type interaction. Concomitant use taxanes cisplatin studied in seven human ovarian carcinoma cell lines, using 96-well plate clonogenic assay. Chemosensitivity expressed terms IC50 values, drug concentration causing 50% inhibition survival. interaction area under survival curve ratios (AUC ratios) by numerical integration. Comparison AUC ratio surviving fraction (SF) value after taxane alone made Student’s t-test. influence tested one-way analysis variance (Anova). A supra-additive or additive seen when lines were exposed paclitaxel docetaxel concomitantly cisplatin. found four (UT-OC-3, UT-OC-4, UT-OC-5 SK-OV-3) simultaneous all concentrations tested, two (UT-OC-4 used paclitaxel. more pronounced docetaxel. degree supra-additivity dose dependent, increasing synergy higher dose. data suggest can be achieved concomitant taxane.
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sci-hub.se 参考文章(28)
V Rantanen, P Engblom, J Kulmala, S Grènman, Paclitaxel and cisplatin sensitivity of ovarian carcinoma cell lines tested with the 96-well plate clonogenic assay. Anticancer Research. ,vol. 16, pp. 1743- 1747 ,(1996)
H. A. Burris, S. Fields, N. Peacock, Docetaxel (Taxotere) in combination: a step forward. Seminars in Oncology. ,vol. 22, pp. 35- 40 ,(1995)
W. G. Thilly, J. G. DeLuca, E. E. Furth, H. Hoppe, D. A. Kaden, J. J. Krolewski, H. L. Liber, T. R. Skopek, S. A. Slapikoff, R. J. Tizard, B. W. Penman, Gene-Locus Mutation Assays in Diploid Human Lymphoblast Lines Chemical Mutagens. pp. 331- 364 ,(1980) , 10.1007/978-1-4613-3072-1_12
Edward K. Russell, Bruce E. Johnson, Adi F. Gazdar, Mark S. Georgiadis, Paclitaxel cytotoxicity against human lung cancer cell lines increases with prolonged exposure durations. Clinical Cancer Research. ,vol. 3, pp. 449- 454 ,(1997)
Eric K. Rowinsky, Martin J. Citardi, Dennis A. Noe, Ross C. Donehower, Sequence-dependent cytotoxic effects due to combinations of cisplatin and the antimicrotubule agents taxol and vincristine Journal of Cancer Research and Clinical Oncology. ,vol. 119, pp. 727- 733 ,(1993) , 10.1007/BF01195344
Reidar Grenman, David Burk, Erkki Virolainen, Ronald N. Buick, John Church, Donald R. Schwartz, Thomas E. Carey, Clonogenic cell assay for anchorage‐dependent squamous carcinoma cell lines using limiting dilution International Journal of Cancer. ,vol. 44, pp. 131- 136 ,(1989) , 10.1002/IJC.2910440123
John J. Gullo, Charles L. Litterst, Patrick J. Maguire, Branimir I. Sikic, Daniel F. Hoth, Paul V. Woolley, Pharmacokinetics and protein binding of cis-dichlorodiammine platinum (II) administered as a one hour or as a twenty hour infusion Cancer Chemotherapy and Pharmacology. ,vol. 5, pp. 21- 26 ,(1980) , 10.1007/BF00578558
V Rantanen, S Grénman, J Kulmala, R Grénman, Comparative evaluation of cisplatin and carboplatin sensitivity in endometrial adenocarcinoma cell lines British Journal of Cancer. ,vol. 69, pp. 482- 486 ,(1994) , 10.1038/BJC.1994.87
Y KIYOZUKA, H NISHIMURA, A NAKASHIMA, K IMAMURA, S OTA, M YAKUSHIJI, S IMAI, M MORIMATSU, IN-VITRO CYTOTOXICITY IN OVARIAN-CANCER OF LOW-DOSE CONTINUOUS EXPOSURE TO MICROTUBULE INHIBITORS (PACLITAXEL TAXOTERE) COMBINED WITH CISPLATIN Oncology Reports. ,vol. 2, pp. 517- 523 ,(1995) , 10.3892/OR.2.4.517
Jose Fernando Diaz, Jose Manuel Andreu, Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition. Biochemistry. ,vol. 32, pp. 2747- 2755 ,(1993) , 10.1021/BI00062A003