Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
作者： A. Kotani , N. Kakazu , T. Tsuruyama , I.-m. Okazaki , M. Muramatsu
关键词: Cytidine deaminase 、 Activation-induced (cytidine) deaminase 、 Biology 、 Somatic hypermutation 、 Immunoglobulin class switching 、 Progenitor cell 、 B cell 、 Lymphoma 、 Transgene 、 Cancer research
摘要: Activation-induced cytidine deaminase (AID), which is essential to both class switch recombination and somatic hypermutation of the Ig gene, expressed in many types human B cell lymphoma/leukemia. AID a potent mutator because it involved DNA breakage not only but also other genes, including proto-oncogenes. Recent studies suggest that required for chromosomal translocation involving cmyc loci. However, unclear whether plays roles tumorigenesis. We examined effect deficiency on generation surface Ig-positive lymphomas Emu-cmyc transgenic mice. Almost all developed AID-deficient mice were pre-B lymphomas, whereas control had predominantly indicating development from overexpressing tumor progenitors. Thus, may play multiple lymphomagenesis.
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sci-hub.se 参考文章(46)
Laura Pasqualucci, Peter Neumeister, Tina Goossens, Gouri Nanjangud, R. S. K. Chaganti, Ralf Küppers, Riccardo Dalla-Favera, Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas Nature. ,vol. 412, pp. 341- 346 ,(2001) , 10.1038/35085588
Tasuku Honjo, Masamichi Muramatsu, Sidonia Fagarasan, AID: how does it aid antibody diversity? Immunity. ,vol. 20, pp. 659- 668 ,(2004) , 10.1016/J.IMMUNI.2004.05.011
Surinder S. Sahota, Zadie Davis, Terry J. Hamblin, Freda K. Stevenson, Somatic mutation of bcl-6 genes can occur in the absence of VH mutations in chronic lymphocytic leukemia Blood. ,vol. 95, pp. 3534- 3540 ,(2000) , 10.1182/BLOOD.V95.11.3534
Freda K. Stevenson, Surinder S. Sahota, Christian H. Ottensmeier, Delin Zhu, Francesco Forconi, Terry J. Hamblin, The occurrence and significance of V gene mutations in B cell—Derived human malignancy Advances in Cancer Research. ,vol. 83, pp. 81- 116 ,(2001) , 10.1016/S0065-230X(01)83004-9
Mardiah Suci Hardianti, Eiji Tatsumi, Meilani Syampurnawati, Kaho Furuta, Aya Suzuki, Katsuyasu Saigo, Seiji Kawano, Mariko Takenokuchi, Shunichi Kumagai, Yoshinobu Matsuo, Tamio Koizumi, Makoto Takeuchi, Presence of somatic hypermutation and activation-induced cytidine deaminase in acute lymphoblastic leukemia L2 with t(14;18)(q32;q21). European Journal of Haematology. ,vol. 74, pp. 11- 19 ,(2005) , 10.1111/J.1600-0609.2004.00338.X
J. M. Adams, A. W. Harris, C. A. Pinkert, L. M. Corcoran, W. S. Alexander, S. Cory, R. D. Palmiter, R. L. Brinster, The c- myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice Nature. ,vol. 318, pp. 533- 538 ,(1985) , 10.1038/318533A0
Takahiro Shirogane, Toshiyuki Fukada, Joyce M.M Muller, David T Shima, Masahiko Hibi, Toshio Hirano, Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity. ,vol. 11, pp. 709- 719 ,(1999) , 10.1016/S1074-7613(00)80145-4
M. S. Gordon, C. M. Kanegai, J. R. Doerr, R. Wall, Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a) Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 4126- 4131 ,(2003) , 10.1073/PNAS.0735266100
V. Poltoratsky, C. J. Woo, B. Tippin, A. Martin, M. F. Goodman, M. D. Scharff, Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 7976- 7981 ,(2001) , 10.1073/PNAS.141222198
Antonius G. Rolink, Jan Andersson, Fritz Melchers, CHARACTERIZATION OF IMMATURE B CELLS BY A NOVEL MONOCLONAL ANTIBODY, BY TURNOVER AND BY MITOGEN REACTIVITY European Journal of Immunology. ,vol. 28, pp. 3738- 3748 ,(1998) , 10.1002/(SICI)1521-4141(199811)28:11<3738::AID-IMMU3738>3.0.CO;2-Q