A process for preparing duloxetine and intermediates for use therein
作者： Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan
DOI:
关键词: Free base 、 Base (chemistry) 、 Salt (chemistry) 、 Organic chemistry 、 Phase-transfer catalyst 、 Chemistry 、 Duloxetine
摘要: A process for preparing (+)duloxetine, or an acid addition salt thereof, which comprises resolving racemic (±)duloxetine with a chiral so as to obtain of the and substantially free (-)duloxetine; (ii) if desired, converting prepared in step (i) base another appropriate. The can further comprise O-alkylation intermediate is carried out presence phase transfer catalyst.
google.com.tr参考文章(12)
Gilbert Stanley Staten, Michael Alexander Staszak, Leland Otto Weigel, Chiral synthesis of 1-aryl-3-aminopropan-1-ols ,(1991)
Mark J. Gattuso, Process for preparation of pharmaceutically desired enantiomers ,(2000)
Edward Ralph Lavagnino, Bennie Joe Foster, 3-Aryloxy-3-phenylpropylamines ,(1981)
Alfio Borghese, Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine ,(2003)
Douglas Patton Kjell, Kurt Thomas Lorenz, Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof ,(2000)
Otto Grawinger, Josef Scholtholt, Thomas Raabe, Eckhard Schraven, Rolf-Eberhard Nitz, Derivatives of 1-phenoxy-3-amino-propan-2-ol ,(1972)
Joseph Herman Krushinski, David Wayne Robertson, David Taiwai Wong, 3-aryloxy-3-substituted propanamines ,(1987)
Mark J. Gattuso, Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers ,(1999)
Jack Deeter, Jeff Frazier, Gilbert Staten, Mike Staszak, Leland Weigel, Asymmetric synthesis and absolute stereochemistry of LY248686 Tetrahedron Letters. ,vol. 31, pp. 7101- 7104 ,(1990) , 10.1016/S0040-4039(00)97251-4
Ahmed Kamal, G.B.Ramesh Khanna, R. Ramu, Chemoenzymatic synthesis2 of both enantiomers of fluoxetine, tomoxetine and nisoxetine: lipase-catalyzed resolution of 3-aryl-3-hydroxypropanenitriles Tetrahedron: Asymmetry. ,vol. 13, pp. 2039- 2051 ,(2002) , 10.1016/S0957-4166(02)00537-2