Organocatalytic Enantioselective Henry Reactions

作者: Yolanda Alvarez-Casao , Eugenia Marques-Lopez , Raquel P. Herrera

DOI: 10.3390/SYM3020220

关键词: Combinatorial chemistryDominoChemistryEnantioselective synthesisStereocenterNitro

摘要: A large number of interesting organocatalytic enantioselective protocols have been explored and successfully applied in the last decade. Among them, Henry (nitroaldol) reaction represents a powerful carbon-carbon bond-forming procedure for preparation valuable synthetic intermediates, such as enantioenriched nitro alcohols, which can be further transformed important nitrogen oxygen-containing compounds. This area research is still expansion more complex version this useful process has recently emerged, domino Michael/Henry protocol, affording highly functionalized cycles with multiple stereogenic centers.

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