Growth and transparency in the lens, an epithelial tissue, stimulated by pulses of PDGF
作者： B Brewitt , J. Clark
关键词: Lens (anatomy) 、 Growth factor 、 Platelet-derived growth factor 、 Pulsatile flow 、 Cell biology 、 Internal medicine 、 Epithelium 、 Epithelial tissue 、 Platelet-derived growth factor receptor 、 Endocrinology 、 In vitro 、 Biology
摘要: The rat lens undergoes dramatic growth during early postnatal development. Lens weight increased by a factor of 23 in 26 days. Growth rate per day oscillated between 0 and 87 percent. A new culture system was designed to study the oscillations transparency vitro required pulsatile delivery platelet-derived (PDGF) HL-1 serum-free medium. Continuous medium with PDGF or without resulted opacity no growth. These results provide direct evidence that stimulates an epithelial tissue occur normal development lens.
sciencemag.org
harvard.edu参考文章(31)
Mireille Delaye, Annette Tardieu, Short-range order of crystallin proteins accounts for eye lens transparency. Nature. ,vol. 302, pp. 415- 417 ,(1983) , 10.1038/302415A0
R. Vornhagen, J. Bours, H. Rink, Immunological Properties of Rat Lens Gamma-Crystallins Ophthalmic Research. ,vol. 15, pp. 126- 130 ,(1982) , 10.1159/000265246
C.V. Harding, H. Rothstein, M.B. Newman, The activation of DNA synthesis and cell division in rabbit lens in vitro Experimental Eye Research. ,vol. 1, pp. 457- IN36 ,(1962) , 10.1016/S0014-4835(62)80038-4
Amanda Pellegrino de Iraldi, J.Pablo Corazza, Perinatal cataract of the rat I. Development, influence of temperature, ultrastructure Experimental Eye Research. ,vol. 29, pp. 145- 153 ,(1979) , 10.1016/0014-4835(79)90080-0
Peter Libby, Elaine W. Raines, Paula M. Cullinane, Russell Ross, Analysis of the mitogenic effect of fetuin preparations on arterial smooth muscle cells: the role of contaminant platelet-derived growth factor. Journal of Cellular Physiology. ,vol. 125, pp. 357- 366 ,(1985) , 10.1002/JCP.1041250302
Jeffrey S. Flier, Lisa H. Underhill, John C. Marshall, Robert P. Kelch, Gonadotropin-Releasing Hormone: Role of Pulsatile Secretion in the Regulation of Reproduction The New England Journal of Medicine. ,vol. 315, pp. 1459- 1468 ,(1986) , 10.1056/NEJM198612043152306
Henry H. Donaldson, Helen Dean King, On the growth of the eye in three strains of the Norway rat American Journal of Anatomy. ,vol. 60, pp. 203- 229 ,(1937) , 10.1002/AJA.1000600203
D. C. Beebe, M. H. Silver, K. S. Belcher, J. J. Van Wyk, M. E. Svoboda, P. S. Zelenka, Lentropin, a protein that controls lens fiber formation, is related functionally and immunologically to the insulin-like growth factors Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 2327- 2330 ,(1987) , 10.1073/PNAS.84.8.2327
J. R. Gavin, J. Roth, D. M. Neville, P. De Meyts, D. N. Buell, Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture Proceedings of the National Academy of Sciences of the United States of America. ,vol. 71, pp. 84- 88 ,(1974) , 10.1073/PNAS.71.1.84
Steve J. Compton, Clive G. Jones, Mechanism of dye response and interference in the Bradford protein assay Analytical Biochemistry. ,vol. 151, pp. 369- 374 ,(1985) , 10.1016/0003-2697(85)90190-3