Establishing Preclinical Withdrawal Syndrome Symptomatology Following Heroin Self-Administration in Male and Female Rats

摘要: Opioid use disorder (OUD) is a significant health problem, and understanding mechanisms of various aspects OUD including drug withdrawal important. Preclinical models provide an ideal opportunity to evaluate underlying opioid withdrawal. Current are limited by their reliance upon forced administration, focus on the acute (and not protracted) syndrome, exclusion females. In this study, male female rats self-administered heroin (maintenance dose 12.5 μg/kg/infusion) after abrupt discontinuation was measured. Phase 1, symptoms were rated in at 0, 16, 48, 72 hr last self-administration session. Total somatic signs increased until 48 (predominantly females), intake positively correlated with total timepoints. Measures hyperactivity anxiety-like behavior 16 hr, respectively. 2, assessed baseline, acute, protracted (168 312 self-administration) timepoints subset from 1. The number did differ across timepoints, though females displayed significantly higher body temperature all compared males, indicating sex-specific symptomatology. These data thorough characterization rodent symptomatology that serve as foundation for future studies designed mimic human experience, demonstrate importance characterizing sex-specificity preclinical self-administration. (PsycInfo Database Record (c) 2020 APA, rights reserved).