Recombinant human IL-2 overcomes genetic nonresponsiveness to malaria sporozoite peptides: correlation of effect with biologic activity of IL-2

摘要: Current malaria vaccine strategies focus on subunit vaccines that contain one or a limited number of Ag. However, there is widespread nonresponsiveness to many these Ag probably resulting from Ir gene control. Using congenic mouse model, we demonstrated human rIL-2 (as an adjuvant) can overcome controlled low immune responsiveness peptide candidates [R32tet32, R32LR, and Th2R-NP (NANP)5NA] as determined by the antibody response, providing it emulsified with during immunization. This effect not caused IL-2 merely acting foreign protein stimulating noncognate help; requires biologic activity IL-2, studying inactive rIL-2, which has minimal but retained its antigenicity. does appear be working priming specific Th, cannot T cell proliferative response. may have role play in development where high titer response required.