Inhibitory constituents against cyclooxygenases from Aralia cordata Thunb.
作者： Nguyen Hai Dang , XinFeng Zhang , MingShan Zheng , Kun Ho Son , Hyeun Wook Chang
DOI: 10.1007/BF02975131
关键词: Aralia cordata 、 Falcarindiol 、 Stereochemistry 、 Glycerol 、 Methylene 、 Pimaric acid 、 Stigmasterol 、 Chemistry 、 Daucosterol 、 Arachidonic acid 、 Chromatography
摘要: Seven diterpenes, four polyacetylenes, a lipid glycerol, and two sterols were isolated from the methylene chloride fraction of root ofAralia cordata. Their chemical structures determined as (-)-pimara-8(14),15-dien-19-oic acid (2), pimaric (3), (-)-kaur-16-en-19-oic (4), 17-hydroxy-ent-kaur-15-en-19-oic (9), 7α-hydroxy-(-)-pimara-8(14),15-dien-19-oic (10), 16α, 17-dihydroxy-(-)-kauran-19-oic (11), 16-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic (12), falcarindiol (5), dehydrofalcarindiol (6), dehydrofalcarindiol-8-acetate (7), falcarindiol-8-acetate (8), alpha-mono palmitin (13), stigmasterol (1), daucosterol (14) by spectral evidences. These compounds tested with COX-1 COX-2 inhibition assays. This study found that compounds2, 4, 5, 6, 7, 8, and10 inhibited dependent conversion exogenous arachidonic to PGE2 in dose-dependent manner IC50 values 134.2 μM, 121.6 170 50.4 11.7 99.6 69.6 respectively. But, most these weakly generation. Among them, only compound 4 showed relatively significant inhibitory activity (IC50: 127.6 μM).
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