Effect of Aralia Cordata Pharmacopuncture on Cartilage Protection and Apoptosis Inhibition In Vitroand in Collagenased-induced Arthritis Rabbit Model
作者： Dong-Suk Park , Yong-Hyeon Baek
DOI:
关键词: Pharmacology 、 Cartilage 、 Chondrocyte 、 Mesenchymal stem cell 、 Traditional medicine 、 Aralia cordata 、 Extracellular matrix 、 Type II collagen 、 Arthritis 、 Osteoarthritis 、 Medicine
摘要: Osteoarthritis (OA) is characterized by structural and biochemical changes in chondrocytes cartilages, insufficient synthesis of extracellular matrix (ECM) because chondrocyte phenotype loss (i.e. dedifferentiation) increased numbers apoptotic 1-5) . Chondrocytes are differentiated from mesenchymal cells during embryonic development. Differentiated synthesize sufficient amounts cartilage-specific ECM, including type II collagen proteoglycan, to maintain integrity 6,7) This homeostasis recognized be destroyed apoptosis the state OA. The current treatments for OA only modify symptoms rather than underlying processes. Therefore, more suitable therapies that pathophysiology needed. At this point, apotosis an essential target received : 15 November 2007 revised 17 accepted 7 December Correspondence Dong-Suk Park Department Acupunture, College Oriental medicine, KyungHee 149, Sangildong, Kangdonggu, Seoul, South Korea (Tel +82-2-440-7702 / Fax +82-2-440-6799 E-mail address: dspark49@yahoo.co.kr) Effect Aralia Cordata Pharmacopuncture on Cartilage Protection Apoptosis Inhibition In Vitro Collagenased-induced Arthritis Rabbit Model
参考文章(23)
Hyun Ah Kim, Yeong Wook Song, Yun Jong Lee, Sang Cheol Seong, Kang Won Choe, Apoptotic chondrocyte death in human osteoarthritis. The Journal of Rheumatology. ,vol. 27, pp. 455- 462 ,(2000)
Linda J Sandell, Pablo Adler, Developmental patterns of cartilage Frontiers in Bioscience. ,vol. 4, pp. d731- ,(1999) , 10.2741/SANDELL
HENRY J. MANKIN, HOWARD DORFMAN, LOUIS LIPPIELLO, ANTRA ZARINS, Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. Journal of Bone and Joint Surgery, American Volume. ,vol. 53, pp. 523- 537 ,(1971) , 10.2106/00004623-197153030-00009
R. Lane Smith, Degradative enzymes in osteoarthritis Frontiers in Bioscience. ,vol. 4, pp. d704- 712 ,(1999) , 10.2741/A388
Linda J Sandell, Thomas Aigner, Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis Arthritis Research & Therapy. ,vol. 3, pp. 107- 113 ,(2001) , 10.1186/AR148
J.-H. Choi, J.-H. Choi, D.-Y. Kim, J.-H. Yoon, H.-Y. Youn, J.B. Yi, H.-I. Rhee, K.H. Ryu, K. Jung, C.-K. Han, W.-J. Kwak, Y.-B. Cho, Effects of SKI 306X, a new herbal agent, on proteoglycan degradation in cartilage explant culture and collagenase-induced rabbit osteoarthritis model Osteoarthritis and Cartilage. ,vol. 10, pp. 471- 478 ,(2002) , 10.1053/JOCA.2002.0526
Nguyen Hai Dang, XinFeng Zhang, MingShan Zheng, Kun Ho Son, Hyeun Wook Chang, Hyun Pyo Kim, KiHwan Bae, Sam Sik Kang, None, Inhibitory constituents against cyclooxygenases from Aralia cordata Thunb. Archives of Pharmacal Research. ,vol. 28, pp. 28- 33 ,(2005) , 10.1007/BF02975131
A.M. DeLise, L. Fischer, R.S. Tuan, Cellular interactions and signaling in cartilage development. Osteoarthritis and Cartilage. ,vol. 8, pp. 309- 334 ,(2000) , 10.1053/JOCA.1999.0306
Francisco J. Blanco, Ram�n Guitian, Eduardo V�zquez-Martul, Francisco J. de Toro, Fausto Galdo, Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis & Rheumatism. ,vol. 41, pp. 284- 289 ,(1998) , 10.1002/1529-0131(199802)41:2<284::AID-ART12>3.0.CO;2-T
John R. Matyas, Mark E. Adams, Dingqiu Huang, Linda J. Sandell, Discoordinate gene expression of aggrecan and type II collagen in experimental osteoarthritis. Arthritis & Rheumatism. ,vol. 38, pp. 420- 425 ,(1995) , 10.1002/ART.1780380320