Early relapses in primary CNS lymphoma after response to polychemotherapy without intraventricular treatment: results of a phase II study

摘要: Background A systemic and intraventricular polychemotherapy regimen (the Bonn protocol) without radiotherapy resulted in durable responses 75% of patients <60 years with primary CNS lymphoma (PCNSL), but was complicated by a high rate Ommaya reservoir infections. Here, the efficacy toxicity this treatment evaluated PCNSL. Patients methods From August 2003 to November 2005, 18 PCNSL (median age, 53 years) were treated phase II trial high-dose methotrexate (MTX; cycles 1, 2, 4 5) cytarabine (Ara-C; 3 6) based therapy including dexamethasone, vinca-alkaloids, ifosfamide cyclophosphamide. Results Study accrual prematurely stopped 2005 due early relapses. Seventeen assessable for response: nine (53%) achieved complete response (CR), two (12%) response/unconfirmed (CRu) partial (PR); four (24%) showed progressive disease (PD). One toxicity. Median follow-up 23 months, median duration only 10 months responding patients, time failure (TTF) 8 whole group. overall survival (OS) has not been reached. Systemic mainly hematologic. Conclusions In years, results rate, is associated relapses majority cases. This contrast same protocol treatment.