Gene expression profiling in the intact and injured brain following environmental enrichment.
作者： Kathy Keyvani , Norbert Sachser , Otto W. Witte , Werner Paulus
关键词: Gene expression 、 Gene expression profiling 、 Environmental enrichment 、 Neuroplasticity 、 Central nervous system 、 Neuroscience 、 Hippocampus 、 Forelimb 、 Cortex (anatomy) 、 Biology
摘要: An enriched environment promotes structural changes in both injured and intact brain improves behavioral performance. In 2 different experimental approaches, the effects of surroundings were analyzed utilizing DNA microarrays. First, gene expression patterns sensorimotor cortex hippocampus noninjured adult rats with housing compared analogous regions kept standard cages. Second, circumscribed infarcts affecting forelimb area induced, non-necrotic ipsilesional as well contralesional homotopic (postlesionally versus standard) analyzed. brain, hippocampus, which had 43 upregulations 15 downregulations showed more than cortex, 13 4 downregulations, indicating a greater responsiveness to environmental stimuli. enrichment led ipsilesionally 28 14 upregulations, while prevailed 46 downregulations. The larger number genes responsive (59 regulations) (i.e. cortex) (17 likely reflects increased susceptibility for plastic due injury. With exception perilesional similar functional groups differentially regulated regions/paradigms, suggesting basically molecular cascades being involved reorganizing following external Many detected here correspond pathways known be neuroplasticity, whereas others provide new hitherto unrecognized entry points.
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