Complex aphthosis: A forme fruste of Behçet's syndrome?

摘要: The evaluation of the rare patient who presents with oral and genital aphthae or almost constant, multiple (greater than 3) aphthae, but no systemic signs symptoms (i.e., complex aphthosis), is difficult because laboratory test available to exclude Behcet's syndrome. Six patients aphthosis were evaluated. In addition, simple aphthosis, those seronegative arthritis, normal controls assessed for circulating immune complexes (CIC) by in vitro vivo assays neutrophil migration subagarose methods, since these tests have given significant results Patient 1, had Raji cell evidence CIC (51.2 mg aggregated human gamma globulin Eq/ml), C1q, C3 dermal blood vessels 4 hours post intradermal histamine injection a Sweet's syndrome-like vasculitis 24 injection. her serum enhanced neutrophils (3.6 +/- 0.6 4.6 0.5; N = 6, p less equal 0.01). All other control negative determinations. Sixteen-month clinical follow-up has confirmed that not Patients 2 developed overt manifestations