Drosophila Nicastrin Is Essential for the Intramembranous Cleavage of Notch
作者： Hernán López-Schier , Daniel St Johnston
DOI: 10.1016/S1534-5807(01)00109-5
关键词: Biology 、 Drosophila Protein 、 Amyloid precursor protein secretase 、 Cell biology 、 Notch signaling pathway 、 Genetics 、 Nicastrin 、 PEN-2 、 APH-1 、 Presenilin 、 Spectrin
摘要: The catalytic subunit of gamma-secretase is thought to be Presenilin, which required for both the cleavage APP and in processing Notch. Presenilin found a multisubunit complex that also contains Nicastrin. Nicastrin has been implicated processing, but its role Notch signaling remains unclear. Here we show Drosophila signaling, acts specifically at S3 step. Partially processed accumulates apically nicastrin presenilin mutant follicle cells. mutations disrupt spectrin cytoskeleton, suggesting another function addition APP.
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