Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

Yue-Ming Li, Min Xu, Ming-Tain Lai, Qian Huang, José L. Castro, Jillian DiMuzio-Mower, Timothy Harrison, Colin Lellis, Alan Nadin, Joseph G. Neduvelil, R. Bruce Register, Mohinder K. Sardana, Mark S. Shearman, Adrian L. Smith, Xiao-Ping Shi, Kuo-Chang Yin, Jules A. Shafer, Stephen J. Gardell, Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1 Nature. ,vol. 405, pp. 689- 694 ,(2000) , 10.1038/35015085

Ekaterina Rogaeva, Ekaterina Rogaeva, Christian Haass, Toshitaka Kawarai, Toshitaka Kawarai, Agnes Supala, Agnes Supala, Masaki Nishimura, Masaki Nishimura, Peter St. George-Hyslop, Peter St. George-Hyslop, Harald Steiner, Fusheng Chen, Fusheng Chen, Paul E. Fraser, Paul E. Fraser, You Qiang Song, You Qiang Song, Erin Holmes, Erin Holmes, Anurag Tandon, Anurag Tandon, Paul Milman, Paul Milman, Dong Mei Zhang, Dong Mei Zhang, Gang Yu, Shigeki Arawaka, Shigeki Arawaka, Mutation of Conserved Aspartates Affects Maturation of Both Aspartate Mutant and Endogenous Presenilin 1 and Presenilin 2 Complexes Journal of Biological Chemistry. ,vol. 275, pp. 27348- 27353 ,(2000) , 10.1074/JBC.M002982200

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski, Thekla S. Diehl, W. Taylor Kimberly, Dennis J. Selkoe, Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. ,vol. 398, pp. 513- 517 ,(1999) , 10.1038/19077

David C. Howell, Statistical Methods for Psychology ,(1987)

M. Nishimura, G. Yu, G. Levesque, D.M. Zhang, L. Ruel, F. Chen, P. Milman, E. Holmes, Y. Liang, T. Kawarai, E. Jo, A. Supala, E. Rogaeva, D -M. Xu, C. Janus, L. Levesque, Q. Bi, M. Duthie, R. Rozmahel, K. Mattila, L. Lannfelt, D. Westaway, H.T.J. Mount, J. Woodgett, P.E. Fraser, P. St George–Hyslop, Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex Nature Medicine. ,vol. 5, pp. 164- 169 ,(1999) , 10.1038/5526

Gary Struhl, Iva Greenwald, Presenilin is required for activity and nuclear access of Notch in Drosophila Nature. ,vol. 398, pp. 522- 525 ,(1999) , 10.1038/19091

Sukanto Sinha, John P. Anderson, Robin Barbour, Guriqbal S. Basi, Russell Caccavello, David Davis, Minhtam Doan, Harry F. Dovey, Normand Frigon, Jin Hong, Kirsten Jacobson-Croak, Nancy Jewett, Pamela Keim, Jeroen Knops, Ivan Lieberburg, Michael Power, Hua Tan, Gwen Tatsuno, Jay Tung, Dale Schenk, Peter Seubert, Susanna M. Suomensaari, Shuwen Wang, Donald Walker, Jun Zhao, Lisa McConlogue, Varghese John, Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature. ,vol. 402, pp. 537- 540 ,(1999) , 10.1038/990114

Yihong Ye, Nina Lukinova, Mark E. Fortini, Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature. ,vol. 398, pp. 525- 529 ,(1999) , 10.1038/19096

Bart De Strooper, Paul Saftig, Katleen Craessaerts, Hugo Vanderstichele, Gundula Guhde, Wim Annaert, Kurt Von Figura, Fred Van Leuven, Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein Nature. ,vol. 391, pp. 387- 390 ,(1998) , 10.1038/34910

Bart De Strooper, Wim Annaert, Philippe Cupers, Paul Saftig, Katleen Craessaerts, Jeffrey S. Mumm, Eric H. Schroeter, Vincent Schrijvers, Michael S. Wolfe, William J. Ray, Alison Goate, Raphael Kopan, A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. ,vol. 398, pp. 518- 522 ,(1999) , 10.1038/19083