CHAPTER 12 – Periaqueductal Gray

摘要: This chapter reviews and discusses the anatomical functional aspects of human Periaqueductal Gray (PAG). The PAG or central gray midbrain is midline structure that encircles mesencephalic aqueduct. It a large made poorly differentiated matter. rich in neuropeptides, it forms an interface between forebrain lower brain stem. There has been considerable attention focused on because its role putative analgesic mechanisms. further presents evidences not homogeneous structure. Behind deceiving cytoarchitecture lies chemical organization suggests existence four longitudinal columns located dorsomedial, dorsolateral, lateral, ventrolateral to appear be important features as they are conserved across mammalian species. noted involved antinociception aversive emotional responses. Although data suggest integrating center for coordinated responses, contribution various these responses remains largely unknown.