Effects of morphine given in the brain stem on the activity of dorsal horn nociceptive neurons.
作者： G.F. Gebhart , S.L. Jones
DOI: 10.1016/S0079-6123(08)62791-0
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摘要: Publisher Summary This chapter discusses the effects of morphine given in brain stem on activity dorsal horn nociceptive neurons. Morphine activates descending systems inhibition, and contributes to analgesia produced. Whether intracerebroventricularly or intracerebrally, inhibits responses stimuli, including withdrawal reflexes organized segmentally, consistent with activation by a system(s) inhibition. Microinjection into midbrain periaqueductal gray (PAG) medullary nucleus raphe magnus (NRM), two sites considered important endogenous pain control, analgesiometric tests either spinally supraspinally. Bulbospinal monoaminergic are activated microinjected PAG NRM antinociceptive morphine, whether systemically attenuated lesions medulla spinal cord receptor antagonists administered intrathecal space.
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sci-hub.se 参考文章(47)
G. F. Gebhart, Modulatory Effects of Descending Systems on Spinal Dorsal Horn Neurons Springer, Boston, MA. pp. 391- 416 ,(1986) , 10.1007/978-1-4684-4994-5_16
LD Aimone, GF Gebhart, Stimulation-produced spinal inhibition from the midbrain in the rat is mediated by an excitatory amino acid neurotransmitter in the medial medulla. The Journal of Neuroscience. ,vol. 6, pp. 1803- 1813 ,(1986) , 10.1523/JNEUROSCI.06-06-01803.1986
J M Besson, A Chaouch, Peripheral and spinal mechanisms of nociception. Physiological Reviews. ,vol. 67, pp. 67- 186 ,(1987) , 10.1152/PHYSREV.1987.67.1.67
Michael R. Vasko, Iok-Hou Pang, Marthe Vogt, Involvement of 5-hydroxytryptamine-containing neurons in antinociception produced by injection of morphine into nucleus raphe magnus or onto spinal cord Brain Research. ,vol. 306, pp. 341- 348 ,(1984) , 10.1016/0006-8993(84)90384-6
A.H. Dickenson, D. Le Bars, Morphine microinjections into periaqueductal grey matter of the rat: Effects on dorsal horn neuronal responses to C-fibre activity and diffuse noxious inhibitory controls Life Sciences. ,vol. 33, pp. 549- 552 ,(1983) , 10.1016/0024-3205(83)90562-3
Zhen-Feng Cheng, Howard L. Fields, Mary M. Heinricher, Morphine microinjected into the periaqueductal gray has differential effects on 3 classes of medullary neurons Brain Research. ,vol. 375, pp. 57- 65 ,(1986) , 10.1016/0006-8993(86)90958-3
John G. Sinclair, The failure of morphine to attenuate spinal cord nociceptive transmission through supraspinal actions in the cat. General Pharmacology-the Vascular System. ,vol. 17, pp. 351- 354 ,(1986) , 10.1016/0306-3623(86)90053-4
A.W. DUGGAN, B.T. GRIERSMITH, R.A. NORTH, Morphine and supraspinal inhibition of spinal neurones: evidence that morphine decreases tonic descending inhibition in the anaesthetized cat. British Journal of Pharmacology. ,vol. 69, pp. 461- 466 ,(1980) , 10.1111/J.1476-5381.1980.TB07035.X
Nicholas M. Barbaro, Donna L. Hammond, Howard L. Fields, Effects of intrathecally administered methysergide and yohimbine on microstimulation-produced antinociception in the rat Brain Research. ,vol. 343, pp. 223- 229 ,(1985) , 10.1016/0006-8993(85)90738-3
Paul J. Camarata, Tony L. Yaksh, Characterization of the spinal adrenergic receptors mediating the spinal effects produced by the microinjection of morphine into the periaqueductal gray. Brain Research. ,vol. 336, pp. 133- 142 ,(1985) , 10.1016/0006-8993(85)90424-X