The failure of morphine to attenuate spinal cord nociceptive transmission through supraspinal actions in the cat.
作者： John G. Sinclair
DOI: 10.1016/0306-3623(86)90053-4
关键词:
摘要: Morphine sulphate was perfused between the third ventricle and cisterna magna in alpha-chloralose anaesthetized cats while recording from multireceptive dorsal horn neurones activated by peripheral noxious radiant heat. concentrations of 10(-5) 10(-4) M were without effect, 10(-3) resulted an increase spinal cord neuronal responses. The results do not support notion that morphine activates a supraspinal mediated descending inhibition which antagonizes nociceptive transmission.
sci-hub.se 参考文章(12)
Abraham Wikler, Harold G. Wolff, Helen Goodell, STUDIES ON PAIN: THE EFFECTS OF ANALGESIC AGENTS ON SENSATIONS OTHER THAN PAIN Journal of Pharmacology and Experimental Therapeutics. ,vol. 83, pp. 294- 299 ,(1945)
Ilmar Jurna, Inhibition of the effect of repetitive stimulation on spinal motoneurones of the cat by morphine and pethidine. Neuropharmacology. ,vol. 5, pp. 117- 123 ,(1966) , 10.1016/0028-3908(66)90057-8
John G. Sinclair, Morphine and meperidine on bulbospinal inhibition of the monosynaptic reflex. European Journal of Pharmacology. ,vol. 21, pp. 111- 114 ,(1973) , 10.1016/0014-2999(73)90214-8
Peter J. Soja, John G. Sinclair, Evidence that noradrenaline reduces tonic descending inhibition of cat spinal cord nociceptor-driven neurones Pain. ,vol. 15, pp. 71- 81 ,(1983) , 10.1016/0304-3959(83)90007-6
J.G. Hall, A.W. Duggan, C.R. Morton, S.M. Johnson, The location of brainstem neurones tonically inhibiting dorsal horn neurones of the cat. Brain Research. ,vol. 244, pp. 215- 222 ,(1982) , 10.1016/0006-8993(82)90080-4
M.H. Ossipov, F.J. Goldstein, R.T. Malseed, Feline analgesia following central administration of opioids Neuropharmacology. ,vol. 23, pp. 925- 929 ,(1984) , 10.1016/0028-3908(84)90006-6
Peter J. Soja, John G. Sinclair, Spinal vs supraspinal actions of morphine on cat spinal cord multireceptive neurons. Brain Research. ,vol. 273, pp. 1- 7 ,(1983) , 10.1016/0006-8993(83)91087-9
Jean-Claude Willer, Studies on pain. Effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man. Brain Research. ,vol. 331, pp. 105- 114 ,(1985) , 10.1016/0006-8993(85)90719-X
I. Jurna, W. Grossmann, The effect of morphine on the activity evoked in ventrolateral tract axons of the cat spinal cord Experimental Brain Research. ,vol. 24, pp. 473- 484 ,(1976) , 10.1007/BF00234964
Huan-Ji Du, Luke M. Kitahata, Johann G. Thalhammer, Manfred Zimmermann, Inhibition of nociceptive neuronal responses in the cat's spinal dorsal horn by electrical stimulation and morphine microinjection in nucleus raphe magnus. Pain. ,vol. 19, pp. 249- 257 ,(1984) , 10.1016/0304-3959(84)90003-4