TRP and Rhodopsin Transport Depends on Dual XPORT ER Chaperones Encoded by an Operon
作者： Zijing Chen , Hsiang-Chin Chen , Craig Montell
DOI: 10.1016/J.CELREP.2015.09.018
关键词: Transport protein 、 Endoplasmic reticulum 、 G protein-coupled receptor 、 Cell biology 、 Rhodopsin 、 Transient receptor potential channel 、 Biology 、 Visual phototransduction 、 Transmembrane protein 、 Drosophila Protein
摘要: TRP channels and G protein-coupled receptors (GPCRs) play critical roles in sensory reception. However, the identities of chaperones that assist GPCRs translocating from endoplasmic reticulum (ER) are limited, ER virtually unknown. The one exception for TRPs is Drosophila XPORT. Here, we show xport locus bicistronic encodes unrelated transmembrane proteins, which enable signaling proteins initiate culminate phototransduction, rhodopsin 1 (Rh1) TRP, to traffic plasma membrane. XPORT-A XPORT-B loss either has a profound impact on Rh1 targeting light-sensing compartment photoreceptor cells. complexed in vivo with homolog mammalian HSP70 protein, GRP78/BiP, which, turn, associated Rh1. Our work highlights coordinated network required biosynthesis channel
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