Intrahippocampal Pathways Involved in Learning/Memory Mechanisms are Affected by Intracerebral Infusions of Amyloid-β25-35 Peptide and Hydrated Fullerene C60 in Rats.

摘要: Primary memory impairments associated with increased level of amyloid-beta (Аβ) in the brain have been shown to be linked, partially, early pathological changes the entorhinal cortex (EC) which spread on the whole limbic system. While hippocampus is known play a key role learning and mechanisms, it is as yet unclear how its structures are involved EC pathology. In this study, neuronal morphology male Wistar rats intrahippocampally injected Аβ25–35 were correlated on days 14 45 after injection reveal specific cognitive - structural associations. The main focus was dentate gyrus (DG) hippocampal areas CA1 CA3 because of their involvement afferent flows from through tri-synaptic (EC  DG  CA1) and/or mono-synaptic pathways. Evident memory impairments observed at both time points injection. However, day 14, populations morphological intact neurons decreased and, drastically, CA1, and DG supramedial bundle significantly damaged. On 45, largely and СА1 partially recovered, whereas remained We suggest that primarily affects pathway, destroying granular cells in the area Schaffer collaterals, CA1. Intrahippocampal pretreatment hydrated fullerene С60 allows their connections survive amyloidosis, thus supporting mechanisms.