Influence of Nanobubble Concentration on Blood-Brain Barrier Opening Using Focused Ultrasound Under Real-Time Acoustic Feedback Control
作者： Bingbing Cheng , Chenchen Bing , Yin Xi , Bhavya Shah , Agata A. Exner
DOI: 10.1016/J.ULTRASMEDBIO.2019.03.016
关键词: In vivo 、 Feedback control 、 Focused ultrasound 、 Biomedical engineering 、 Microbubbles 、 Circulation time 、 AKA 、 Blood–brain barrier 、 Materials science
摘要: Real-time acoustic feedback control based on harmonic emissions of stimulated microbubbles may serve as a way to achieve reliable blood-brain barrier (BBB) opening with focused ultrasound in the brain. Previously, we demonstrated BBB was possible using sub-micron bubbles (aka nanobubbles) and produced comparable results commercially available (Optison, Definity, etc.). The were observed be more consistent nanobubbles, which warrants further study these agents. This examined nanobubbles at different concentrations both vitro vivo evaluated under real-time across concentrations. Original (1011 bubbles/mL) have long persistence (7.3 ± 3.3 min) circulation time rats (approximately 10 exposures this study, degraded dilutions. With all three tested dilutions (1:1, 1:10 1:100), successful reliably achieved control.
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