Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System.

摘要: Central nervous system (CNS) disorders encompass a vast spectrum of pathological conditions and represent growing concern worldwide. Despite the high social clinical interest in trying to solve these pathologies, there are many challenges bridge order achieve an effective therapy. One main obstacles advancements this field that has hampered therapeutic strategies proposed date is presence CNS barriers restrict access brain. However, adequate brain biodistribution neuronal cells specific accumulation targeted site also major hurdles attainment successful treatment. Over last few years, nanotechnology taken step forward towards development therapeutics neurologic diseases different approaches have been developed surpass obstacles. The versatility designed nanocarriers terms physical chemical properties, possibility functionalize them with moieties, resulted improved neurotargeted delivery profiles. With concomitant progress biology research, inspired by nature advantage physiological processes delivery. Here, nanosystems targeting moieties used reported open literature comprehensively reviewed critically discussed, emphasis on most recent bioinspired advances field. Finally, we express our view paramount need be overcome for promising move from bench bedside.