Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit.

摘要: Abstract Ethnopharmacological relevance Equisetum giganteum has been traditionally used as an anti-diabetic herbal remedy to treat diabetes in the southern state of Rio Grande do Sul Brazil. Aim study Considering ethonopharmacology and historical importance E. giganteum, its potential antidiabetic effect was evaluated alloxan induced diabetic rabbits. Material methods Samples were collected city Ouro Preto, Minas Gerais, Butanolic aqueous extracts prepared subsequently for properties vivo using albino male At end treatment period, animals euthanized, histopathological analysis carried out. The following biochemical parameters studied: glucose, triacylglycerol, cholesterol, albumin, creatinine, glycosylated hemoglobin lipase. phytochemical profile studied by liquid chromatography techniques coupled a UV/VIS detector high-resolution mass spectrometry. Results Both butanolic capable reducing significantly levels cholesterol triacylglycerol thus demonstrating their hypolipidemic hypoglycemiant effects. Furthermore, prevented occurrence hepatic complications during treatment. investigated, natural products detected agreement with those that had previously described literature. Conclusion Based on significant reductions histologic evidence absence liver, pancreas treated animals, can be therapeutically relevant resource hyperlipidemia.