Translating insights from the cancer genome into clinical practice
作者： Lynda Chin , Joe W. Gray
DOI: 10.1038/NATURE06914
关键词: Bioinformatics 、 Computational biology 、 Human genome 、 Genomics 、 Human genetics 、 Genome 、 Carcinogenesis 、 Biology 、 Epigenomics 、 Epigenetics 、 Cancer
摘要: Cancer cells have diverse biological capabilities that are conferred by numerous genetic aberrations and epigenetic modifications. Today's powerful technologies enabling these changes to the genome be catalogued in detail. Tomorrow is likely bring a complete atlas of reversible irreversible alterations occur individual cancers. The challenge now work out which molecular abnormalities contribute cancer simply 'noise' at genomic epigenomic levels. Distinguishing between will aid understanding how cell collaborate drive pathophysiology. Past successes converting information from discoveries into clinical tools provide valuable lessons guide translation emerging insights end points can affect practice medicine.
nature.com
harvard.edu
elsevier.com
osti.gov
utsystem.edu参考文章(95)
Mark Pegram, Dennis Slamon, Biological rationale for HER2/neu (c-erbB2) as a target for monoclonal antibody therapy. Seminars in Oncology. ,vol. 27, pp. 13- 19 ,(2000)
J D Rowley, The role of chromosome translocations in leukemogenesis. Seminars in Hematology. ,vol. 36, pp. 59- 72 ,(1999)
Francis S Collins, Anna D Barker, Mapping the cancer genome. Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies. Scientific American. ,vol. 296, pp. 50- ,(2007)
Laleh Shayesteh, Yiling Lu, Wen-Lin Kuo, Russell Baldocchi, Tony Godfrey, Colin Collins, Daniel Pinkel, Bethan Powell, Gordon B. Mills, Joe W. Gray, PIK3CA is implicated as an oncogene in ovarian cancer Nature Genetics. ,vol. 21, pp. 99- 102 ,(1999) , 10.1038/5042
Steven E. Artandi, Ronald A. DePinho, Mice without telomerase: what can they teach us about human cancer? Nature Medicine. ,vol. 6, pp. 852- 855 ,(2000) , 10.1038/78595
Steven E. Artandi, Sandy Chang, Shwu-Luan Lee, Scott Alson, Geoffrey J. Gottlieb, Lynda Chin, Ronald A. DePinho, Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice Nature. ,vol. 406, pp. 641- 645 ,(2000) , 10.1038/35020592
J. M. Stommel, A. C. Kimmelman, H. Ying, R. Nabioullin, A. H. Ponugoti, R. Wiedemeyer, A. H. Stegh, J. E. Bradner, K. L. Ligon, C. Brennan, L. Chin, R. A. DePinho, Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies Science. ,vol. 318, pp. 287- 290 ,(2007) , 10.1126/SCIENCE.1142946
A G Uren, J Kool, A Berns, M van Lohuizen, Retroviral insertional mutagenesis: past, present and future Oncogene. ,vol. 24, pp. 7656- 7672 ,(2005) , 10.1038/SJ.ONC.1209043
Sreenath V. Sharma, Daphne W. Bell, Jeffrey Settleman, Daniel A. Haber, Epidermal growth factor receptor mutations in lung cancer Nature Reviews Cancer. ,vol. 7, pp. 169- 181 ,(2007) , 10.1038/NRC2088
Francis S. Collins, Anna D. Barker, Mapping the Cancer Genome Scientific American. ,vol. 296, pp. 50- 57 ,(2007) , 10.1038/SCIENTIFICAMERICAN0307-50