Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
作者： Mark J W Hanssen , Joris Hoeks , Boudewijn Brans , Anouk A J J van der Lans , Gert Schaart
DOI: 10.1038/NM.3891
关键词: Brown adipose tissue 、 Insulin resistance 、 GLUT4 、 Cold acclimation 、 Insulin receptor 、 Internal medicine 、 Endocrinology 、 Type 2 Diabetes Mellitus 、 Biology 、 Diabetes mellitus 、 Type 2 diabetes
摘要: Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 °C) increased peripheral insulin sensitivity ∼43% in eight type 2 subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on signaling or AMP-activated protein kinase (AMPK) activation only minor increase BAT glucose uptake.
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