Telomerase and the cell cycle
作者： Tej Krishan Pandita
DOI: 10.1016/S1566-3124(01)08004-X
关键词: DNA polymerase 、 Somatic cell 、 Telomerase reverse transcriptase 、 RNA 、 Molecular biology 、 Cell biology 、 Biology 、 Telomerase 、 Telomerase RNA component 、 Cell 、 Telomere
摘要: Publisher Summary Telomerase is a ribonucleoprotein complex that elongates telomeres. activity present in unicellular organisms and germ cells, both situations it expected to play role for indefinite cycling protection from shortening of the Telomeres contain distinctive repeats guanine-rich sequences are replicated by DNA-dependent DNA polymerases telomerase dependent synthesis telomeric an RNA template. consists proteins complexed with essential intrinsic part enzymatic active complex. mammals ubiquitous embryonic tissues but downregulated most somatic tissues. activation controlled cellular proliferation, early step development many tumors. Normal human cells have finite life span vivo as well vitro retire into senescence after limited number cell divisions.
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