Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline

摘要: It is well established that aging associated with metabolic dysfunction such as increased adiposity and impaired energy dissipation; however, the transcriptional mechanisms regulating balance during late life stages have not yet been fully elucidated. Here, we show ablation of nuclear receptor PPARγ specifically in inguinal fat tissue mice expansion insulin resistance. These effects are accompanied by decreased thermogenesis, reduced levels brown genes, browning subcutaneous adipose tissue. Comparative studies downregulation young mid-aged demonstrate a preferential regulation gene programs an age-dependent manner. In conclusion, our study uncovers essential role for maintaining expenditure process suggests possibility targeting to counteract age-associated dysfunction.