Role of forkhead box protein A3 in age-associated metabolic decline

摘要: Aging is associated with increased adiposity and diminished thermogenesis, but the critical transcription factors influencing these metabolic changes late in life are poorly understood. We recently demonstrated that winged helix factor forkhead box protein A3 (Foxa3) regulates expansion of visceral adipose tissue high-fat diet regimens; however, whether Foxa3 also contributes to increase decrease brown fat activity observed during normal aging process currently unknown. Here we report aging, levels significantly selectively up-regulated inguinal white depots, midage Foxa3-null mice have browning thermogenic capacity, decreased expansion, improved insulin sensitivity, longevity. gain-of-function loss-of-function studies depots a cell-autonomous function for browning. Furthermore, our analysis revealed mechanisms modulation gene programs involve suppression peroxisome proliferator activated receptor γ coactivtor 1 α (PGC1α) through interference cAMP responsive element binding 1-mediated transcriptional regulation PGC1α promoter. Overall, data demonstrate role energy expenditure age-associated disorders.