Peroxisome Proliferator-Activated Receptor-α Deficiency Does Not Alter Insulin Sensitivity in Mice Maintained on Regular or High-Fat Diet: Hyperinsulinemic-Euglycemic Clamp Studies

摘要: Chronic peroxisome proliferator-activated receptor (PPAR)-alpha activation improves glucose metabolism in rodent models of insulin resistance and diabetes; however, PPAR-alpha deficiency was also reported to protect against high-fat diet (HFD)-induced resistance. The aim this study clarify the role development using knockout (KO) mice wild-type controls (WT). Both WT KO on HFD gained significantly more weight relative chow-fed groups displayed an increase levels a decrease adiponectin levels. Hyperinsulinemic-euglycemic clamp performed nonfasting state demonstrated that caused marked reduction whole body, muscle, white brown adipose tissue uptake both groups. Suppression endogenous production during markedly blunted HFD-fed mice, indicating liver magnitude HFD-induced changes parameters sensitivity comparable mice. In conclusion, these data show does not alter fed normal chow as measured by hyperinsulinemic-euglycemic nonfasted state.